We have recently published the first ever large-scale study of the gut microbiome of 110 healthy individuals from distinct locations in India using multi-omics approaches, including 16S rRNA gene amplicon sequencing, whole genome shotgun metagenomic sequencing, and metabolomic profiling of faecal and serum samples.The study reveals the unique composition of Indian gut microbiome, establishes the Indian gut microbial gene catalogue, and compares it with the gut microbiome of other populations. The functional associations revealed using metagenomic and metabolomic approaches provide novel insights on the gut-microbe-metabolic axis, which will be useful for future epidemiological and translational researches. The study is published in 'GigaScience' journal in 2019.
This is the first Metagenomic study of the scalp microbiome worldwide, and also the first and very large scale study (~1000 samples) from India, which has not only identified the abundance of bacterial and fungal species on the scalp but also explained their role in maintaining a healthy scalp. Novel role was found for the bacteria residing on the scalp in supplying the scalp with nutrients which are essential for a healthy scalp. The study provides an excellent sample of a successful industry-academia collaboration between IISER Bhopal and Loreal research and Innovation in India and France. The study is published in 'Frontiers in Cellular and Infectious Microbiology' journal in 2018.
Autism spectrum disorder (ASD) is a term associated with a group of neurodevelopmental disorders. To identify the taxonomic composition and markers associated with ASD, we compared the fecal microbiota of 30 ASD children with family-matched 24 healthy children from Indian population using next-generation sequencing (NGS). Our study showed prominent dysbiosis in the gut microbiome of ASD children, and an association of selected Lactobacillus species with the gut microbiome of ASD children. The study is published in 'Microbial Ecology' journal in 2018.
We have carried out the metagenomic sequencing and analysis of hot springs in Central India including Tattapani and Anhoni hot springs. The analysis revealed the hydrocarbon degrading thermophiles and pathways essential for the survival of thermophilic microbial communities in these extreme environments.
We are carrying out a large scale metagenomic project to reveal the unique microbial diversity present in the ocean water and mangroves of Andaman Islands. We have also isolated, cultured and sequenced several novel bacteria from these unique locations.